Down regulation of anti-inflammatory cytokines in ileal mucosa associates with active disease in juvenile idiopathic arthritis
نویسندگان
چکیده
Methods We performed gastroduodenoscopy and colonoscopy in 16 children with JIA suffering from gastrointestinal (GI) symptoms. The control children (n=25) had GIsymptoms, but eventually were shown not to have any significant GI disease. We analyzed in duodenal and ileal biopsy samples the mRNA expression of IFNg, TGFb, IL6, IL4, FoxP3, IL17A, CTLA4, ICOS, GITR, IL10, IL18, IL12p40, IL23, TLR2, TLR4, and TLR5 with RT-PCR. We also assessed correlation between the clinical markers of JIA and the mucosal mRNA levels.
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